生化学と分析生化学

概要

Study of Related Biochemical Tests and PTH in End Stage Renal Disease Patients in Iran

Abdolrahim Poor Heravi S, Zarebavani M, Einollahi N, Safari F and Dashti N

Introduction: End-stage renal disease (ESRD) patients usually have abnormalities in various laboratory tests. The aim of this study is evaluating of the rate of various laboratory tests in ESRD patient to reduce the risk of mortality and prevent them of other diseases.
Methods: In this cross-sectional study a total of 300 patients who had ESRD and had been on hemodialysis treatment for at least 6 months were selected. The laboratory tests consisted of measurement of high density lipoprotein, triglyceride, cholesterol, fasting blood sugar, parathyroid hormone, alanine transferase, aspartate transferase, alkaline phosphatase, creatinine, blood urea nitrogen, calcium, phosphorous, sodium, potassium, and albumin.
Results: The study population included 52.3% males and 47.7% females with average age of 41.5 ± 14.3 years. The high serum level of Chol (˃200 mg/dL) and TG (˃160 mg/dL) are 48.7%, 32.3%, respectively. About 98% were in high risk of range HDL (˂45 mg/dL). All of participants had over normal range of BUN and about 96% of them were over normal range of Cr. Rate of high serum level of Na, K, P, and Ca were 3.7%, 52%, 54.3%, and 14.6%, respectively.
Discussion: Depend the result of this study, can understand that great group of patients with ESRD have high risk serum level of lipid indexes. Recent studies showed that there is a clear correlation between HDL cholesterol and cardiovascular risk in ESRD patients and there is correlation between level of triglyceride level and CKD progression. The important risk factors for involving in ESRD are hyperphosphatemia, hypercalcemia, dyslipidemia, and hypoalbuminemia which impact on CVD morbidity directly.
Conclusion: In this study observed that most of patient with ESRD have abnormality in their lipid profiles factors, mineral electrolytes factors, and PTH. Regular laboratory checkup can control renal failure (especially ESRD patients) patients. Proper care of body, balanced diet intake, plenty water intake during the day can help them to control these diseases.