生化学と分析生化学

概要

Physical, Chemical, Strategies with Antimicrorna and Recombinant Virus to Deliver Genes into Hepatic Tissues. Assement of miRNA Reprogramming and its Gene Networks

Ehab Oraby

Hepatocellular carcinoma (HCC) is a deadly malignancy with limited treatment options (1) HCC is a heterogeneous disease ,the occurrence of gene aberrations, cellular context, and environmental influences are good promotor for tumor initiation, progression, and metastasis( 2) The molecular mechanisms underlying progression of HCC is not clear. So it is important to investigate the target molecules and molecular mechanisms that sharing in development and progression of HCC for development of effective diagnostic and therapeutic strategies (2).The dysregulation of miRNAs is hall mark of cancer and also play a maior role in the pathogenesis of multiple cancer including HCC,the expression of. miRNAs exert its effect through regulation of oncogenes and tumor suppressor genes that involved in pathway of cell signaling. Therefore MiR-221/222 have been considered either oncogenes or tumor suppressors gene , so it can regulate the cell cycle, apoptosis and metastasis (3).miR-222 is most significantly down-regulated miRNA. the miR-221/222 family having high degree of homology.