生化学と分析生化学

概要

Mangifera indica Extract (Vimang) Restored the Redox Balance in Type-1 Diabetic Patients

MCs Dalyla Alonso Rodriguez, Dra Ela Moreno Tellez, Frank E Medina Ali and Dra Idalia Sanchez Morell

In diabetes mellitus, atherosclerosis is early, rapid, and widespread, affecting the dyslipoproteinemia secondary to hyperglycemia, lipoproteins glycosylation produced changes, making them more atherogenic and generate free radicals that cause apoprotein oxidation of lipids and macromolecules nearby, we decided to evaluated the presence of oxidative stress in children with Diabetes mellitus type-1 and demonstrated the need for antioxidants as part of drug therapy of this disease. Thirty ambulatory patients of Endocrinology were selected between 6 to 12 years of age, who had been suffering from Diabetes mellitus type-I since 3 years ago. Under their informed consent of the selected group the seric levels of antioxidant was tested: uric acid, vitamin C, bilirrubin, ceruloplasmin, albumin and cholesterol, LDL- cholesterol, HDL-cholesterol, triglycerides, oxidized LDL, Vimang tablets (300 mg/24 h) was supplied for three month, and the same tests were repeated every month. Data was processed by means of descriptive statistics methods, with of absolute and relative frequency distribution, performing a hypothesis test for paired observations.