生化学と分析生化学

概要

Increased Levels of Inflammatory Marker hsCRP, MDA and Lipid Profile in Non-obese Hypertension Subjects

Nakkeeran M, Priasamy S, Inmozhi SR, Santha K and Sethupathy S

Introduction: High sensitive C-reactive protein (hsCRP) is a very sensitive marker of inflammation, which is synthesized in the liver and has been a widely used biomarker for risk stratifying in Cardio vascular disease (CVD). It is positively correlated with abdominal fat and closely correlated with increased risk of cardiovascular events and obesity had the predominant association with cytokine levels. Obesity induces systemic oxidative stress and causes dysregulation of adipo cytokines and development of metabolic syndrome. In our study, we investigated hsCRP levels in non-obese hypertensive subjects on treatment and its relationship with oxidative stress and lipid profile.
Methods: Patients with secondary hypertension, past history of stroke, coronary artery disease, myocardial infarction, and diabetes mellitus were excluded. Serum lipid profile and thiobarbituric acid reactive substances, hsCRP were estimated in these patients by standard procedures and the values were compared with healthy controls. Totally 160 subjects were included in the study.115 were considered as Hypertension with blood pressure >140/90 mmHg and 45 as healthy controls after obtaining consent.
Results: There is significant difference in hsCRP levels between study groups, and hsCRP levels correlate with blood pressure. The level of MDA and hsCRP levels were significantly increased in hypertensive subjects compared to control group.
Conclusion: Our study shows that even in non-obese hypertensive subjects there was significant increase of hsCRP, LDL Cholesterol. Hence elevated hsCRP levels in addition to lipid profile screening may be a valuable tool for prediction of CVD risk in hypertensive subjects.