生化学と分析生化学

概要

Effect of Glucosamine-Derivate Molecules on the Extracellular Matrix Remodeling In Human Dermal Fibroblast

Cardone Michele and Cocchiola R

Skin is the largest human organ that undergoes alterations due to the passage of time. It is subject to direct environmental challenge; especially the most common source of damage is solar ultraviolet (UV) irradiation. The photoaging affects the phenotype of different cellular type such as keratinocytes, fibroblasts and dendritic cells either by direct effects of irradiation on the cells or indirectly by the remodel and aged extracellular matrix (ECM). Inappropriate ECM composition is involved in several skin pathologies as well as in skin aging. Previous studies in our lab have been focused on the effect of glucosamine (GlcN) and an its peptydil-derivatives 2-(N-Acetyl)-Lphenylalanylamido- 2-deoxy-β-D-glucose (NAPA) and 2-(NCarbobenzyloxy)- L-phenylalanylamido-2-deoxy-β-D-glucose (NCPA), to induce ECM production and the inhibition of IKKα activation in human dermal fibroblasts, as potential new drug for aging and skin disorders treatment.