生化学と分析生化学

概要

Computing the Reflexes Regulating Blood Pressure and it's Components in Response to Various Pathological and Physiological Factors in Healthy Adolescents.

Shantala S. Herlekar*

An observational study was directed on healthy youth in the age group of 18-22yrs to assess the influences of various physiological and pathophysiological components on individual element of blood pressure. Cardiovascular reflexes were re-gauged to explain probable mechanism for observations made. The results from 120 normotensive subjects helped us revalidate following hypothesis on blood pressure regulatory mechanisms; gender difference showed lower BP elements in females probably due to estrogens protective role on both cardia and vasculature through nitric oxide induction and more. Significant negative correlation of age was seen with RPP hypothesising early and reduced cardiac oxygen extraction. BMI correlated positively with BP proposing changes within circulating blood volume, cardiac output and large vessels. No correlation was seen between handedness and BP element. The extended biopsychosocial model and active baroreceptor reflex have been used to explain influences of acute perceived stress on BP unlike baroreceptor resetting seen during acute physical stress. Rumination, cardiovascular refashioning, reflex adaptation and resetting may be probable explanations for the BP changes seen with chronic perceived stress.