ジャーナル・オブ・ファーマコビジランス

概要

An Idea of Using Drug Combination Therapy through Dissolving Microneedles to Treat Streptozotocin-nicotinamide Induced Diabetic Rats

Mohd Yaqub Khan, Min-Hua Chen

Micro-needle transport approach has been used from past few a long time as a method to break the stratum corneum
layer of skin and to perform the effective transport of drug across the skin and it is especially used for delivery
of peptides, protein, DNA, oligonucleotides, molecular mass medicine and inactivated viruses across the dermal
layer of the skin. In this hypothetical paper, we specifically targeted on how we will develop double-layer microneedle
which can deliver drug-mixture therapy efficaciously. Because there are many diseases together with cancer,
tuberculosis, diabetes, leprosy, HIV, and AIDS, which may be efficiently handled by way of drug-combination
therapy however this remedy is particularly confined to the tablet, capsule or another form of dosage. If we can
develop double- layered micro-needles, can an opportunity to treat these illnesses with painless delivery. In the
paper, we have tried to deal with type-2 diabetes with double-layered micro needle and that is formulated with the
aid of hypothetically designed capsule which has the projection in it and which may be connected with projection
of primary micro-needle and can form cone-like cavities and from these cavities we will deliver our drug and materials
for the development of secondary layer on a primary layer of micro-needle and this technique can be utilized in
different disease remedy and it is going to reduce fee of treatment, increase in patient compliance, site directed
drug-delivery, increase in bioavailability of drug in the blood stream and increase in therapeutic index with less side
effects.