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Wound Pathophysiology: Insights of Ca2+ Signaling and Cellular Senescence Mechanisms in Healing, and Regeneration
Rajiv Kumar
Cellular senescence and calcium signaling are interrelated phenomena of cellular events. As, cellular senescence is associated with stress, alongside it, intracellular calcium signaling has a concern with cellular senescence. Henceforth, both events participate in wound regeneration and governed few of its phases (re-epithelialization, tissue remodeling, inflammation, and granulation). Despite it, mitochondrial Ca2+ uptake influences the phenomena of fibroblast and my fibroblast differentiation. Quantitative imaging and computational modeling expose hidden features of calcium signaling route. A proper investigation of the role of calcium in specific senescence-associated routes and physiopathological conditions will expose forefront of calcium signaling and its association with cellular senescence.