老化科学ジャーナル

概要

Utilizing the Klotho Protein and Second-Generation Growth Factors for the Treatment of Facial Photoaging: A Clinical Experience with Ten Cases

Gail Humble, Rianna Mendiola

Chronic exposure to solar ultraviolet irradiation and other environmental toxins can result in facial fine lines due to loss of elasticity in the skin.urther, this can result in poor skin texture, and loss of trans-epidermal water loss. The Klotho gene was originally identified as an age-suppressing gene in mice that extends life span when overexpressed. It induces complex phenotypes resembling human premature aging syndromes when disrupted. The gene was named after a Greek goddess Klotho who spun the thread of life. The Klotho gene is the first documented aging suppress or gene in mammals that can delay aging when overexpressed and accelerate aging when disrupted UV-related skin diseases are a major concern in public health. In view of the cell injury induced by UVB, Klotho protein may be an ideal therapy to eliminate UVB-induced cell damages due to aging. This study evaluated the efficacy of utilizing the Klotho protein in a cell conditioned medium in a serum, and its use on ten patients. The application of the Klotho protein and second-generation growth factor in a serum was found highly effective in improving visible signs of photoaging, inclusive of texture and wrinkles.