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Utilization of Crosslinked Starch Nanoparticles as a Carrier for Indomethacin and Acyclovir Drugs
Gina S El-Feky, El-Rafie MH, MA El-Sheikh, Mehrez E El-Naggar and Hebeish A
An eco-friendly nanoprecipitation technique was put forward to synthesize native starch nanoparticles loaded with insoluble drugs such as indomethacin (IND) and Acyclovir (ACV). Factors studied to find out the optimum conditions for preparation of different formulations of crosslinked starch nanoparticles (TPP-StNPs) loaded with insoluble drugs. The factors are 20 mg, 50 mg of drug concentration and 0.5, 1 g of sodium tripolyphosphate (STPP) while the concentration of starch and surfactant were kept constant. World-class facilities as particle size analyzer, poly dispersity index (PDI), zeta potential, TEM, XRD, FT-IR, UV-vis spectroscopy and DSc were used for evaluation of the resultant crosslinked starch nanoparticles loaded with drug. The sustained release of drugs were evaluated using entrapment efficiency and in vitro release. The data obtained confirmed that there is no chemical interaction between drug (IND, ACV) and crosslinked starch nanoparticles. The results indicate that the best formula for IND loaded starch nanoparticles was 0.5 g STPP and 20 mg IND while the best formula for ACV nanoparticles was at 0.5 g STPP and 50 mg ACV drug.