臨床および医療生化学

概要

Urinary Melatonin Levels and Endothelial Dysfunction in Non Obese Hypertension Subjects

Nakkeeran Mathivanan*, Santha K, Inmozhi Sivakamasundari R

Introduction: Melatonin, the principal product of the pineal gland, is metabolized in the liver mainly to 6- sulfatoxymelatonin. Melatonin is reason for diseases, like cancer, hypertension, depression and diabetes; its secretion is influenced by environmental light As this substance is mostly excreted by urine, urinary 6-sulfatoxymelatonin is considered a good index of melatonin production In vascular diseases, endothelial dysfunction is a systemic pathological state of the endothelium and can be broadly defined as an imbalance between vasodilatation and vasoconstriction substances produced by the endothelium. Endothelial dysfunction can result from and/or contribute to several disease processes, as occurs in hypertension, hypercholesterolemia, diabetes and it can also result from environmental factors, such as from smoking tobacco products and exposure to air pollution.

Objective: To investigate the association of urinary 6 sulfatoxymelatonin levels and endothelial dysfunction in hypertension subjects.

Methods: 63 hypertensive subjects without cause of any secondary hypertension. 35 subjects were control in this study, total of 98 subjects were studied. Subjects with secondary hypertension, past history of stroke, coronary artery disease, myocardial infarction were excluded from this study.

Results: The systolic and diastolic blood pressure considered to be elevated in hypertensive patients and statistically significant when compared to the control group. Our study shows a significant difference between urine aMT6s and NO in hypertension subjects compare to control.

Conclusion: The results suggest that melatonin and nitric oxide levels are low in subjects with hypertension, thus endothelial dysfunction precedes and predicts the development of hypertension.