臨床研究と生命倫理ジャーナル

概要

Unveiling the Unforeseen: Diclofenac-Triggered Near-fatal Rapid Onset Asthma in a Stable Asthmatic Individual Managed by NIV-A Unique Case Report

NMM Risly*

This case report details a 35 years old woman with a history of mild intermittent asthma, who presented with rapid- onset severe respiratory distress shortly after ingesting oral diclofenac sodium for neck pain. Despite being well-controlled with inhalers for over a year, patient developed near-fatal asthma, characterized by severe hypoxia, hypercapnia and altered mental status, requiring immediate, multidisciplinary interventions. The patient was treated with high-flow oxygen, back-to-back nebulizations and Non-Invasive Ventilation (NIV) using Bilevel Positive Airway Pressure (BiPAP), resulting in significant clinical improvement. This case highlights the rare but severe risk of Nonsteroidal Anti-Inflammatory Drugs (NSAID)-induced asthma exacerbations and signifies the importance of prompt recognition and aggressive treatment in managing life-threatening asthma episodes.