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Topical therapy of 1-2, 4, 5 Trimethoxy phenyl 1' methoxypropionaldehyde in experimental Tinea pedis in Wistar rats
Subha TS, *Gnanamani A
Dermatophytic infections are cutaneous, restricted to nonliving cornified layers because of the inability of the fungi to penetrate deeper into immunocompetent hosts. The current therapeutics includes azoles, allylamines, and polyenes. The unfavourable side effects and the resistance exhibited by the fungus demand new drugs. Acorus calamus is a traditional Indian medicinal plant used for curing epilepsy, insomnia etc. In the present study, in vivo efficacy of 1- 2, 4, 5 trimethoxy phenyl-1' methoxy-propionaldehyde (TMPMP) was evaluated using Wistar rats. Dermatophytic infection was created in the Wistar rats using T. rubrum in the plantar region of rats. The infection was monitored using physical, microscopic, and microbiological observations. Therapy was topical application of TMPMP on infection site for 7 days. The curing of infections was again monitored by physical, microscopic, and microbiological observations.