微生物および生化学技術ジャーナル

概要

Theoretical Study of Quinoline Derivatives Involved in Neurodegenerative Diseases

Soufi Wassila, Faiza Boukli-Hacene, Meriem Merad and Said Ghalem

Neurodegenerative diseases include more than 600 affections that alter the structures of the brain, the best-known being Alzheimer's disease and Parkinson's disease. These diseases can influence an individual’s movement, speech, memory, intelligence, and much more; because neurodegenerative diseases are so complex. Although, it remains a mystery why only degeneration happens in neurodegenerative diseases. A series of quinoline derivative has been synthesized with a very high heterocyclic class in a wide range of biological activities. These derivatives have been shown to be selective inhibitors of Acetylcholinesterase (AChE) with IC50 values. This work is to study the inhibition of AChE enzyme involved in the Alzheimer's disease by computational methods for molecular modeling and simulation of macromolecule. These results will probably help in the development of an effective therapeutic tool to fight against the development of Alzheimer's disease.