幹細胞研究と治療のジャーナル

概要

The Metabolic Change of Serum Dehydroepiandrosterone Sulfate, Free Fatty Acids and Desaturase Activity in Isolated Post-Challenge Hyperglycemia

Liyan Liu, Ying Li and Changhao Sun

The aim of this study is to investigate the association between endogenous dehydroepiandrosterone sulfate (DHEA-S) and fatty acid, desaturase in isolated post-challenge hyperglycemia (IPH) subjects. 241 IPH subjects aged 35 to 70 years participated. Serum DHEA-S concentration was measured using the enzyme-linked immunosorbent assays. Fatty acid profiles were detected by gas chromatography-mass spectrometry, and desaturase activities were expressed by fatty acid product-to-precursor ratios. Relationships were assessed using multiple regression. The results suggested that DHEA-S concentration was negatively associated with palmitic acid (P < 0.001), and positively with γ-linolenic acid and eicosatetraenoic acid in men (P = 0.002 and P = 0.001, respectively), and negatively with palmitic acid (P = 0.037) and positively with docosapentaenoic acid, docosahexaenoic acid (P = 0.018 and P < 0.001, respectively) in women. In addition, a positive association was observed between DHEA-S and delta-9-desaturase (D9D-18, P = 0.031) in men, and also delta-6-desaturase (D6D, P = 0.034) in women. In Conclusions, there is different DHEA-S, fatty acid profile and the desaturase activities in both genders with the IPH subjects.