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The effect of ethanolic extract of Moringa oleifera on alcohol-induced testicular histopathologies in pre-pubertal albino Wistar rats
Rosemary B Bassey, Danladi N Bala, Innocent A Edagha, Aniekan I Peter
Excessive use of alcoholic beverages has identified alcoholism as one of modern societyâs major problems. This study was carried out to investigate the effect of Moringa oleifera on alcohol-induced testicular toxicities in prepubertal Wistar rats. Forty pre-pubertal Wistar rats were divided into 10 groups. Group 1âcontrol, Group 2âM. oleifera only, Group 3âalcohol and then M. oleifera, Group 4âalcohol and M. oleifera, Group 5âM. oleifera and then alcohol, Group 6âalcohol only, Group 7âalcohol and then vitamin C, Group 8âvitamin C and alcohol, Group 9âvitamin C and then alcohol, and Group 10âvitamin C only. Alcohol caused numerous atrophies in the testes and damaged spermatogenic cells. M. oleifera and vitamin C however exhibited protective and reversibility effects. Results showed significant effect of M. oleifera on the testicular weight without any significant difference in body weight. In conclusion, M. oleifera ameliorates alcohol-induced testicular toxicities with its antioxidant properties comparable to vitamin C.