血液疾患と輸血ジャーナル

概要

The Biological Structure of Platelet and their Role with Subpopulations in Haemostasis

Fahad SM Alshehri*, Salem SS Alqahtani, Anwar MS Alraizah

Platelets are the smallest blood cells which circulated in the blood in inactive status. It is activated during the blood vessel injury to stop the bleeding through formation of platelet plug. It is also enhance the coagulation pathway by expose of Phosphatidylserine (PS) to increase the generation of thrombin and thereby increase the activation of other platelets. The unique structure of platelets supports them to do multifunction in different aspects. There are a different platelet populations based on their functions and their ages. In this review we aim to write overview of platelets including the structure, receptors, functions in adhesion and aggregation and identify the platelet subtypes and their role in haemostasis and thrombosis.