患者ケアジャーナル

概要

The Amino Acid Pool in Oncology: Plastic Substrates, Specific Regulators of Metabolism and Markers

Karavay P, Karavay N and Nefyodov L

On the basis of experimental data we suggest that discovered differences in certain amino acids concentrations in blood plasma, red blood cells and tumors are criteria in early diagnostic of primary cancerous growth as well as, in estimation of the effectiveness of specific cancer treatment. In clinical studies (1,495 patients with cancer of mammary gland, lungs, prostate, ovaries, bladder or digestive tract) biological fluids and tumors of cancer patients significant changes of physiological concentrations of amino acids real or indirectly regulate processes of the antitumor response, oncogenesis, immunogenesis and apoptosis were shown. Our strategy of application of amino acids as medicinal preparations includes a directional effect on the functional and metabolic relationships which change in specific pathology through the effect on the regulatory mechanisms of intermediate metabolic reactions, limiting stages of metabolic flows, utilization of energy substrates and transport systems restricting the processes of amino acids pool formation. The creation methodology of pathogenetic compositions of amino acids and their derivatives on the basis of their physiological concentration for practical application in oncology of their regulatory effects was discussed.