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Targeting of Somatostatin Receptors Using Fluorescent Nanoparticles
Ahmed A.H. Abdellatif
The main goal of this work was to recognize how nanoparticles target certain sites in the body with certain targeting peptides to specific receptor by active targeting. The study focused on the methods of preparation and the characterization of quantum dots (QDs) carrying a PEG-amine which were conjugated to somatostatin to give QDs- SST. This was followed by successful cellular uptake experiments. The results showed a successful characterization for QDs-conjugated SST. Cellular uptake showed highly specific interactions with cells using flow cytometry and inductively coupled plasma optical emission spectroscopy. The QDs-SST can be displaced from their receptor, which relates to the specificity of the interaction with somatostatin receptor. In conclusion, SST can deliver the nanoparticles to the targeted sites with high drug delivery efficacy in vitro due to decoration with SST.