幹細胞研究と治療のジャーナル

概要

Stem Cells for Neurovascular Repair in Stroke

Kazutaka Shinozuka, Travis Dailey, Naoki Tajiri, Hiroto Ishikawa, Dae Won Kim, Mibel Pabon, Sandra Acosta, Yuji Kaneko and Cesar V Borlongan

Stem cells exert therapeutic effects against ischemic stroke via transplantation of exogenous stem cells or stimulation of endogenous stem cells within the neurogenic niches of subventricular zone and subgranular zone, or recruited from the bone marrow through peripheral circulation. In this paper, we review the different sources of stem cells that have been tested in animal models of stroke. In addition, we discuss specific mechanisms of action, in particular neurovascular repair by endothelial progenitor cells, as key translational research for advancing the clinical applications of stem cells for ischemic stroke.