生体分子研究と治療学ジャーナル

概要

Status of T2D In Punjabi Indian Females Based on Risk Variable Factor Analysis

Nabodita Kaul, Singh YP, Badaruddoza and Bhanwer AJS

Problem Statement: Obesity, hypertension and glucose levels have been associated with the risk of T2D development. Body Mass Index (BMI), Waist-Hip Ratio (WHR) are the indicators of obesity, Systolic blood pressure (SBP) and Diastolic blood pressure (DBP) are the indicators of hypertenion and fasting blood sugar (FBS) and Random blood sugar (RBS) are the indicators for glucose levels. Independent association of these markers with T2D has been reported earlier but no information is available on the association of T2D employing Principal Component Factor Analysis (PCFA) in North Indian population. Present study is an attempt to assess the influence of these diverse parameters in multi ethnic cohort of North Indian Punjabi females. Approach: The study included a total of 492 females (242 diabetic cases and 250 healthy controls) belonging to Punjabi population. Following literature survey, proforma was designed to accommodate required anthropometric and physiometric parameters. PCFA was used to extract orthogonal factors from anthropometric and physiometric variables. Results: PCFA of 9 interrelated risk parameters, extracted 5 main factors (SBP, DBP, FBS, RBS, BMI and WHR) associated with increased risk of T2D in diabetic Punjabi females. The analysis also revealed that, these factors can independently act as risk predictors in diabetics as compared to non diabetics. Conclusion: Based on the data, we construe that blood pressure and glucose levels are the most significantly parameter associated with increased the risk of T2D in Punjabi females.