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概要
ウイルス性肝炎、マンソン住血吸虫症および重複感染患者における肝線維症の非侵襲性マーカーとしての血清ヒアルロン酸（HA）および可溶性細胞間接着分子-1（Sicam-1）
カディガ・アハメド・イスマイル、サバ・アブドゥ・エル・ガニー・アハメド、ノハ・アブデル・ファッタ・エルバディ
Background: This study aimed to correlate serum Hyaluronic Acid (HA) and soluble intercellular adhesion molecule-1 (sICAM-1), with severity of liver fibrosis as clinically and histologically assessed in viral hepatitis, schistosomiasis mansoni and co-infected patients.
Methods: The study was performed on 4 groups: Group 1 (G1) 15 chronic hepatitis patients; Group 2 (G2) 15 chronic schistosomiasis mansoni co-infected with chronic hepatitis patients; Group 3 (G3) 15 chronic schistosomiasis mansoni without hepatitis patients; Group 4 (G4) 15 active schistosomiasis mansoni without hepatitis patients.
Results:The results showed a significant high level of HA and sICAM-1 in all groups compared to G4, while a significantly high level of HA in G2 compared to G3. There was a highly significant positive correlation between the level of HA and sICAM-1 and between both of them, and Child-Pugh clinical classification of patients with higher levels in Child-Pugh C. Also, serum level of both HA and sICAM-1 was positively correlated to the severity of liver fibrosis assessed by biopsy, with a highly significant higher level in advanced stages 4 and 5.
Conclusions: HA and sICAM-1 showed good diagnostic performance and could discriminate severe from mild liver fibrosis, enabling them to be used as valuable non-invasive markers to identify and follow up patients with liver fibrosis.