アレルギーと治療のジャーナル

概要

Self-Imposed Food Restriction and Oral Food Challenges are correlated with Precipitin?s Accuracy in the Diagnosis of Non-Ige Mediated Food- Related Adulthood Acute Episodes of Urticaria

Celso Eduardo Olivier, Daiana Guedes Pinto, Regiane Patussi dos Santos Lima, Ana Paula Monezzi Teixeira, Jhéssica Letícia Santos Santana

Background: The diagnosis of non-IgE mediated food allergy is done mainly by in vivo Oral Food Challenge (OFC) tests that depend on well-succeeded previous exclusion diets.

Objective: To evaluate the opportunity of the in vitro semi-quantitative research of specific precipitins to select food allergens to proceed with exclusion diets and further in vivo oral food challenge tests in food-allergic patients.

Methods: The tube titration of specific precipitins against food allergens in food allergic patients was compared with the in vivo oral food challenge tests performed after a well-succeeded exclusion diet. The probability of a positive or negative OFC was estimated according to the precipitin’s titrimetry.

Results: The correlation coefficient between the precipitin’s titrimetry and the probabilities of a positive OFC was 0,76 (p=0.017).

Conclusion: The semiquantitative research of specific precipitins against food allergens is a useful triage test to select food allergens to proceed with exclusion diets and oral food challenges to diagnose non-IgE mediated food allergy in adults with recurrent episodes of acute urticaria.