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Screening of Antagonistic Marine Actinomycetes: Optimization of Process Parameters for the Production of Novel Antibiotic by Amycolatopsis Alba var. nov. DVR D4
Venkata Ratna Ravi Kumar Dasari, Murali Yugandhar Nikku and Sri Rami Reddy Donthireddy
Screening of six marine sediment samples near NTPC of the Visakhapatnam (India) Coast of Bay of Bengal resulted in the isolation of 72 isolates of actinomycetes. Among these, Amycolatopsis alba var. nov. DVR D4 showed broad antibacterial activity spectra against Gram-positive and Gram-negative bacteria; and produced antibacterial metabolite extracellulary under submerged fermentation conditions. The chemical and physical process parameters affecting the production of the antibiotic were optimized. The maximum antibiotic activity was obtained with the optimized production medium containing D-glucose, 2.0 %w/v; malt extract, 4.0 %w/v; yeast extract, 0.4 %w/v; dipotassium hydrogen phosphate, 0.5 %w/v; sodium chloride, 0.25 %w/v; zinc sulphate, 0.004 %w/v; calcium carbonate, 0.04 %w/v; with inoculum volume of 5.0 %v/v at 6.0 pH, 28 ° C incubation temperature, 220 rpm and for 96 h incubation.