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Safety and Efficacy of Amniotic Membrane Implant in Venous Leg Ulcers
Marinello J, Serra-Prat M, Albuxeich C, Carreño P, Lopez-Palencia J, Palomera E and Alos J
Objective: To assess the safety and efficacy of amniotic membrane (AM) application in venous leg ulcers (VLU).
Methodology: Design: non-controlled pre-post clinical trial. A unique AM fragment was placed on the ulcer in strict sterility conditions. Main outcome measures: total healing rate, percentage of ulcer area reduction and diurnal and nocturnal pain assessment. Control visits: at baseline and 1, 2, 3, 4 and 8 weeks after treatment.
Results: Ten patients were recruited (79.6 years). 3 weeks after AM implant, pain had completely disappeared and ulcer area had reduced to nearly halved and, 8 weeks after AM implant, ulcer area was reduced in more than 80% and in two thirds of patients the ulcer was completely healed. No relevant side effects were observed.
Conclusions: The present study brings new evidence reinforcing the idea that AM dressing is a safety and effective alternative to heal VLU