臨床および実験薬理学ジャーナル

概要

Rheumatoid Arthritis: Prescription Trends at Tertiary Care Hospitals

Aditya Ashri*, Anjoo Kamboj, Hitesh Malhotra

Rheumatoid arthritis is one of the most prevalent auto-immune diseases impacting the world’s population, causing joint inflammation, synovium growth, and articular cartilage degradation. Inflammatory cells (B-cells, T-cells and macrophages) secrete lysosomal enzymes, which damage cartilage and erode bones, while the PG produced in the process causes vasodilation and pain. RA is a chronic, progressive, and disabling disease with hair loss and damage. Many small joints of the hands and feet are generally affected; Deformities are created as the disease progresses.

Objectives: The purpose of this study was to examine the pattern of usage of antirheumatic medicines in a tertiary care hospital in Mohali, India.

Methods: The research included 85 individuals who were receiving antirheumatic medication. The demographic information of the patient, co-morbid conditions, medicines prescribed, and Adverse Drug Reactions (ADRs) were utilised to examine the pattern of drug usage.

Results: Only one patient was administered sulphasalazine, while nine others were prescribed hydroxychloroquine alone. Methotrexate and hydroxychloroquine were the most often prescribed DMARDs combination, accounting for 23% of all prescriptions. Methotrexate, sulphasalazine, and hydroxychloroquine were the most often given three DMARDs, i.e., six times.

Conclusion: The most often given drugs were DMARDs, vitamin-D3 and calcium supplements, and analgesics, according to the drug prescription pattern. From NLEM 2015, 75.40% of medications were prescribed.