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Review of HPLC and LC-MS/MS Methods for Determination of ZT-1 and Its Active Metabolite, Huperzine A in Various Biological Matrices
Suresh PS
Huperzine A is an alkaloid isolated from Huperzia serrata. It belongs to anticholinesterase class and used for neurological conditions like Alzheimer’s disease. Huperzine A is the metabolite of ZT-1, which is also used for the treatment of memory disorders and inhibits the effect of enzyme and brings back sufficient levels of acetylcholine. This review provides an overview of various HPLC, LC-MS and LC-MS/MS methods for quantitation of Huperzine A alone or along with ZT-1 in different biological fluids (plasma, serum and blood). In addition, this review provides complete details on sample preparation, extraction recoveries, matrix effect, internal standard selection, selectivity optimization, chromatographic separations, mass spectrometric spectrometry and other detection techniques etc.