ナノメディシンとナノテクノロジーのジャーナル

概要

Report of Initial Experience with a Novel Extracellular Matrix Material Derived from Porcine Urinary Bladder to Treat Patients with Vesico- Vaginal Fistula

Tomasini JM, Jose Flores, Pagliara T, McAdams S, Palma I and Nakib NA

Abstract Our objective was to report our initial experience with extracellular matrix material derived from porcine urinary bladder, MatriStem, in patients with vesico vaginal fistula (VVF). Materials and methods: For our retrospective review, we obtained the medical records of 40 consecutive patients who were seen for VVF during our 2 years study period. All patients underwent a thorough evaluation, including history, physical, examination, computed tomography urography, and single-dye pad tests. The cases were treated with two different kinds of MatriStem to repair VVF. Results: In 6 patients, the MatriStem procedure was performed by robotic surgery, in these cases a MatriStem graft were used; in 3 cases we injected micronized particles of MatriStem via cystoscopy and vaginoscopy. The mean follow-up 7.25 months. We observed that 75% of the cases had no fistula drainage per the vagina and progressed to full healing. Conclusion: MatriStem in our early results seem to have a role in effectively treating VVF. Further investigation and long term follow up is needed to establish MatriStem as An alternative treatment for VVF patients.