微生物および生化学技術ジャーナル

概要

Relevance of the T cell Receptor-Ligand Avidity for Immunity to Infection

Magdalena Nauerth, Kristof Wing, Heinrich Korner and Dirk H Busch

Cytotoxic lymphocytes are critical for fighting viral and certain bacterial infections. Therefore, assessing the quality of cytotoxic T cell responses might have important clinical implications. TCR-pMHC binding (avidity) is a key determinant of T cell quality. Here we review currently available technologies for the measurement of TCR-pMHC avidity and their potential relevance for translational applications.