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Quality evaluation of lipid-lowering activity of Phyllanthus amarus (Schumacher) leaf extract
RP Umbale*, GS Mathe, DV Jawalkar, SM Patil, SS Dongale
Atherosclerosis, termed as the "silent killer," is one of the leading causes of death in developed countries and is also on the rise in developing countries such as India. Hence, therapists consider treatment of hyperlipidemia as one of the primary approaches to slow down the atherogenic process. There are many allopathic lipid-lowering drugs in the market, but their popularity has declined due to side effects and contraindications. Recently, herbal lipid-lowering drugs have gained importance to fill the void created by allopathic drugs. The present study was conducted to evaluate the antihyperlipidemic effect of Phyllanthus amarus Schumach plant on cholesterol diet-induced hyperlipidemia in Wistar rats. The in vivo antihyperlipidemic potential of hydroalcoholic extract of Phyllanthus amarus Schumach leaves (HAEPAS) was studied using a cholesterol diet-induced hyperlipidemia model in rats. The study results showed that HAEPAS exhibited a significant lipid-lowering effect at doses of 300 and 500 mg/kg.