生物学と医学

概要

Age-dependent platelet activity in experimental dyslipidemic rats

Zabarishina SYu, Kutafina NV, Vatnikov UR, Makrina ON, Kulikov EV, Listtsova EO, Gurina RR, Sotnikova ED.

The aim of this paper is to clarify the age-dependent platelet activity level in rats with experimental dyslipidemia. In this study, 105 healthy male rats (34 12-month-old rats, 32 18-month-old rats, and 39 24-month-old rats) were included in the study, which modeled dyslipidemia. The control group included 91 healthy male rats (30 12-month-old rats, 32 18-month-old rats, and 29 24-month-old rats) under standard housing conditions. Biochemical, hematological, and statistical methods were applied. In the control rats, a gradual increase in functional platelet activity was observed with increasing age. Dietary modeling of dyslipidemia in rats resulted in a significant increase in platelet activity with increasing age of the experimental animals. Dyslipidemia models in rats of different ages showed weakened plasma antioxidant protection and increased plasma LPO, which became more severe with increasing age of the studied animals. The impaired development of the experimental rats exceeded the age-related changes in platelet activity in the control group.