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Pharmacokinetic Study of Lappaconitine Hydrobromide Transfersomes in Rats by LC-MS
Zheng WS, Sheng YX, Zhang YJ, Fang XQ and Wang LL
A rapid and sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed for determination of lappaconitine hydrobromide in rat plasma and study on the pharmacokinetics of lappaconitine hydrobromide transfersomes in rat. Analyses were performed on AltimaTM HP C18 column (50 mm×2.1 mm, 3 μm) with internal standard of tetrahydropalmatine and a mobile phase of methanol-0.1% formic acid (80:20). Agilent™ LC/ MSD QQQ mass spectrometer with the mode of multiple reactions monitoring (MRM) was applied in the detection. Pharmacokinetic parameters of isodose lappaconitine hydrobromide transfersomes in transdermal patch were analyzed and calculated by DASver 2.0 software. The results indicated that with the linear range of 2.0-2000.0 ng/ml, quantitative lower limit was 2.0 ng and both the inter-day and the intra-day precisions were less than 9.9%. Lappaconitine hydrobromide transfersomes could significantly increase AUC and extend the circulation time of in rats.