薬理ゲノミクスと薬理プロテオミクスのジャーナル

概要

Pharmacogenomics of Cytochrome P450 Dependent Metabolism of Endogenous Compounds: Implications for Behavior, Psychopathology and Treatment

Anna Persson and Magnus Ingelman-Sundberg

Mood and anxiety disorders are a major burden to the society today but still the pathophysiology behind these disorders is largely unknown and the pharmacotherapy available today is far from sufficient, with relatively low remission rates. Recent results regarding the action of CYP2C19 and CYP2D6 in the CNS suggest associations between suicidality, anxiety and other stress-related disorders and such CYP enzyme polymorphisms. Knowledge about the CNS specific action of these enzymes might in the future provide an increased understanding of the pathogenesis and pathophysiology of these disorders. Here we present an update of the research carried out in human and animal models with focus on the roles of CYP2C19 and CYP2D6 for brain development and function mediated by the metabolism of endogenous compounds.