微生物および生化学技術ジャーナル

概要

New Generation Antibiotics/Antibacterials: Deadly Arsenal for Disposal of Antibiotic Resistant Bacteria

Monica Sharma, Shashank Singh and Sidharth Sharma

Inappropriate prescribing, lack of compliance in taking medicines and wise spread uncontrolled use of drugs led to emergence of multidrug resistance in clinically important infectious agents. Over 480000 new cases of multidrug-resistant tuberculosis (MDR-TB) were reported by WHO in the year 2013 in hundred countries world wide. Therefore, there is an urgent need for new generation antibacterial which can effectively and precisely act on drug resistant bacteria. Different strategies of development of resistance in bacteria involve the changes at molecular level like mutations, over expression of enzymes and efflux. So, the strategies of antibiotics development can include methods which can counteract at molecular level like antisense antibacterial and inhibition of quorum sensing. Bacterial gene rpoD found in Staphylococcus species is highly conserved and became basis in creation of antisense antibacterial against it. Lipid II class of antibiotics including teixobactin and antimicrobial peptides (AMPs), i.e. produced synthetically, have also shown promising results against the resistant bacterial strains. The present review summarizes the current scenario on research and development of new age antibiotics and techniques to tackle drug resistant bacterial infection.