脳障害と治療

概要

mTOR Silencing in Parkinson's Disease both in vitro and in vivo

Mohamed Salama

Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates processes including mRNA translation, proliferation, and survival. As a central element signaling cell growth and enhancing protein translation, (mTOR), when inhibited, induces autophagy. Moreover, as a critical feedback mechanism, reactivation of mTOR terminates autophagy and initiates lysosome reformation