臨床および実験薬理学ジャーナル

概要

Model Based Description of the Pharmacokinetic Behavior of Pentobarbital in Fasted Male Volunteers after Oral Administration of 10 mg of Pentobarbital

Maria Durisova*

The goal of the current study was to present a further example which showed a model based description of the pharmacokinetic behavior of pentobarbital in fasted male volunteers after oral administration of 10 mg pentobarbital. The current study is a companion piece of the earlier study by Smith et al.; therefore the data published in the study cited here were used. For modeling purposes, an advanced modeling method based on the theory of dynamic systems was employed. All mathematical models developed, more or less successfully described the data of healthy male volunteers after oral administration of capsules containing 50 mg of sodium pentobarbital. The modeling method used in the current study is universal and uniform. Therefore, it can be used to develop mathematical models not only in pharmacokinetics but also in several other scientific and practical fields. This modeling method could augment, or in future replace, a variety of different modeling methods traditionally used in pharmacokinetics.