生物学と医学

概要

Micro RNA as Biomarkers and Tool for Target-Based Treatment in Patients with Inflammatory Bowel Diseases

Alexander E Berezin and Eugene I Poplyonkin

Inflammatory bowel diseases (IBD) are common group of digestive inflammatory disorder, which characterized defective regulation of adaptive immunity. There are raised evidences that intercellular cooperation affected epithelial cells, macrophages and dendritic cells play a pivotal role in gut homeostasis. Therefore, dysregulation of cell cooperation may lead to decreased epithelial integrity and worsening of IBD. Recent pre-clinical and clinical investigations have shown that micro RNAs are involved in several pathological processes affected cell-to-cell cooperation, transferring information, tissue repair mediating, angiogenesis and neo-vascualrization. The mini review is discussed the potential role of micro RNAs as biomarkers and tool for target-based treatment in patients with inflammatory bowel diseases