ナノメディシンとナノテクノロジーのジャーナル

概要

Mesoporous Silica Nanospheres Functionalized by Tio2 as a Photoactive Antibacterial Agent

Krzysztof Cendrowski, Magdalena Peruzynska, Agata Markowska-Szczupak, Xuecheng Chen, Anna Wajda, Joanna Lapczuk, Mateusz Kurzawski, Ryszard J. Kalenczuk, Marek Drozdzik and Ewa Mijowska

In this contribution we present comparative study on synthesis, bio-characterization and antibacterial properties of mesoporous silica nanospheres modified by titanium dioxide. Mesoporous silica nanospheres functionalized by titania were studied as light activated antibacterial agents. The analysis of the antibacterial effects on E. coli ATCC 25922 shows strong enhancement during the visible and ultraviolet light irradiation in respect to the commercial catalyst and sample free from the nanomaterials. In darkness the mesoporous silica/titania nanostructures revealed low antibacterial activity dependent on the stirring intensity of the suspension containing nanomaterials and bacteria. The nanomaterials toxicity was determined on the amount of lactate dehydrogenase released from mouse fibroblast cells L929 with LDH assay. Sample was characterized in details by means of high resolution transmission electron microscopy (HR-TEM), Raman spectroscopy, XRD and BET Isotherm.