臨床研究と生命倫理ジャーナル

概要

Mechanisms of the Solid Cancer Induced by Atomic Bomb and the Spontaneous Cancer in the Daily Life-Proposal of a New Medical Treatment for Cancers-Review

Hiroshi Baba, Akihiko Yokoyama

Incidence rates of radiation-induced cancers and spontaneous cancers observed in the daily-life were analyzed to construct mathematical models respectively. Resulting models reproduced observed incidence rates satisfactorily. The former model is a two-stage process, damaging of a chemical bond in a cell by radiation and succeeding mutation of the damaged cell to a cancer. The latter is a one-stage process evoked by cell division.

For radiation-induced cancers, the curing effect was clearly observed for mild environmental radiation. Regrettably, no data are available for the effect of mild-level radiation on the spontaneous cancer observed daily-life, however the possibility that the damaged cell is affected by mild radiation is high since the damage caused by cell division should be much more severe compared to the collision with radiation.