発がんと突然変異誘発のジャーナル

概要

Inflammation: Cancer's Friend or Foe?

Shrihari T.G

Inflammation is a response to noxious stimuli. Acute inflammation induced release of inflammatory mediators involved in protective role by repair and regeneration. Chronic progressive, persistent inflammation induced release of chronic inflammatory mediators involved in tumor progression by tissue damage, DNA damage, Gene mutation, cell proliferation, cell survival, invasion and metastasis by activation of a key transcription factor such as NF-KB. This article briefs about the acute and chronic inflammatory mediator’s protective and promotive role in tumor.