熱帯病と公衆衛生ジャーナル

概要

In Vitro Activity Screening of Snake Venom against Multi Drug Resistant Tuberculosis

Sujay Kumar Bhunia, Mrinmoy Sarkar, Sananda Dey, Arpita Bhakta, Antony Gomes and Biplab Giri

The re-emergence of multidrug-resistant tuberculosis (MDR-TB) events has brought to light the importance of screening effective novel drugs. In the present study, in vitro activities of different snake (Naja naja, Bungarus fasciatus, Daboia russelli russelli, Naja kaouthia) venoms have been investigated against clinical isolate of MDR-TB strains. All the venoms inhibited the mycobacterial growth for at least a week in common and two of them (Naja naja, Naja kaouthia) showed significantly longer inhibition up to two weeks against the MDR-TB strain with single dose and one repetition of those two venoms exhibited inhibition up to more than 4 weeks.