血液疾患と輸血ジャーナル

概要

In a Thai population, HLA Markers of Drug Hypersensitivity

Pravasini Sethi

SCARs, such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reactions with eosinophilia and systemic symptoms (DRESS), are potentially life-threatening cutaneous reactions triggered by a number of medications. Due to the hemolytic anemia caused by ribavirin, which increased the number of blood transfusions, this therapy has been restricted to thalassemia and SCD patients. HLA alleles, which encode human antigen-presenting proteins, have recently been discovered to be valid pharmacogenetics markers for predicting these life-threatening reactions.