新生児生物学ジャーナル

概要

Importance of Monitoring Cerebral Blood Flow in Preterm Neonates

Tatjana Radunovic Gojkovic*, Vera Zdravkovic

Objectives: Aim of this paper is to establish prognostic significance and reliability of Doppler ultrasound measurement of cerebral blood flow in preterm neonates with intracranial hemorrhage. Methods: A prospective study based on the Doppler ultrasonography by measuring the resistance index (RI) through an anterior cerebral artery, in 50 premature neonates with diagnosed intracranial hemorrhage. The obtained results are grouped on the values of resistance index, RI into three groups and were analyzed using arithmetic mean, standard deviation, testing the significance of the average difference, T-test. Results: There were significant differences p<0.05, between the RI values of RI1 and RI2 lower than 0.61 during the first and during the second examination. Statistical analysis values RI1 and RI2 lower than 0.85 and higher than 0.61, shows that there were differences between value RI1 and RI2 in premature newborns with intracranial hemorrhage, p<0.05. There were significant differences between values RI1 and RI2 higher than 0.85, p<0.05. There were significant differences between RI values lower than 0.61 in the first, and in the second ultrasound examination p<0.05. We found significant difference between the two groups of values RI1 and RI2 in patients with PDA, p<0.05. Conclusions: With increasing gestational age RI is decreasing. With increasing body weight RI is decreasing. With closing PDA, RI is decreasing. Doppler neurosonography is the method of choice, which is now used in the measurement of neonatal cerebral circulation, or for non-invasive testing neonatal brain perfusion.