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Genotoxicity Assessment of Zinc Oxide Nanoparticles in Male Rats After Oral Administration Using Micronuclei and Comet Assay
Gamal Hassan Mohamedin*, Amal Ramadan G, Eissa G, Ahmed Yassein AM
In the food and fertilizer industries, zinc oxide nanoparticles (ZnO-NPs) are frequently utilized. In our investigation, rats received oral administration of ZnO NPs with a particle size of 30 ±5 nm once daily at doses of 100, 200, 300, 400, and 500 mg/kg for ten weeks in order to assess the genotoxic effect. Impacts on hematological markers, genotoxic impact, and growth were investigated. The results indicated that ZnO-NPs significantly reduced body weight gain, red blood cell count (RBC), hemoglobin concentration (Hb), hematocrit value (HCT), and platelet count (PLT), while increasing white blood cell (WBC), mean capsular volume (MCV), mean capsular hemoglobin (MCH), and mean capsular hemoglobin concentration (MCHC) in the treated rats. Our data show a dosage-dependent increase in DNA fragmentation for both the comet assay and the micronuclei test, which was supported by an increase in the proportion of DNA that was tail-containing, the length and intensity of DNA tails, and the tail moment, especially at the dose of 500 mg/kg. The findings revealed an increase in the number of micronucleated cells.