臨床および医療生化学

概要

Four Selected Sudanese Medicinal Plants Induce Anticancer and Cytotoxic Effects in Prostate Cancer Cell Line

Montasir Ahmed Elnour, Fatima Penech and Mohamed Ahmed Mesaik

Sudanese medicinal plants have been used in treating human diseases for thousands of years used locally in traditional medicine. This work investigated the anticancer, antioxidant and Cytotoxicity activities of four Sudanese Medicinal Plants commonly used as anti-inflammatory and anti-tumor. Hibiscus sabdariffa L. fruits, Sonchus oleraceus L. leaves, Halexylon salicornietum (MAB) whole plant, Prosopis juliflora (SW) DC leaves. All the plant parts were extracted using 80% methanol, the anticancer activity was examined by using MTT assay against PC3 (prostate cancer) cell lines and determine their antioxidant activities by testing Chemiluminescence activity, cytotoxicity using - (4, 5-Dimethyl thiazole-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT), filter and kept in dark, prepared freshly. The extract Prosopis juliflora (SW.) DC has shown very high activity against-PC3 and Hibiscus sabdariffa has shown very high activity against-PC3 the extract Halexylon salicornietum and Sonchus oleraceus L has shown none active anti- PC3 with IC50 values 30.1, 94.7, >100, and >100 μg/ml respectively. All the extracts revealed cytotoxicity activity against Vero cell line except last concentration in extract of Sonchus oleraceus L, and the inhibition percentage with (90.56, 87.12, 86.24) (82.78, 82.31, 77.38) (75.21, 59.49, 41.24) (74.93, 73.78, 71.13) respectively. The extracs of Hibiscus sabdariffa, Halexylon salicornietum and Sonchus oleraceus L. are revealed low active against Chemiluminescence assay, Prosopis juliflora (SW) DC is revealed high active against Chemiluminescence assay with IC50 values 166.6, 189.5, >176.2 and 75.4 μg/ml respectively.