生物学と医学

概要

Formation of Neutrophil Extracellular Traps against Infection and During Inflammation: Boon or a Bane?

Sultan Z Alasmari

Neutrophils are the first line of innate immune defence against pathogens. They have three different processes for directly attacking microorganisms, including phagocytosis, degranulation, and forming neutrophil extracellular traps (NETs). The methods of degranulation and phagocytosis are well established. However, several recent studies have been conducted to understand the potential role of NETs in diseases. The involvement of NETs was shown in several conditions including infections and inflammation. This review will discuss the morphology and mechanisms of NET formation, as well as NET formation against infection and during inflammation.