細菌学および寄生虫学ジャーナル

概要

Fatal Invasive Trichosporonosis Caused by Trichosporon inkin after Allogeneic Stem Cell Transplant for very Severe Idiopathic Aplastic Anemia

Daphné Krzisch, Vincent Camus, Marion David, Gilles Gargala, Stéphane Lepretre*

Invasive Trichosporon inkin fungal infections are rare and unusual, occurring nearly exclusively in immunocompromised patients experiencing prolonged neutropenia during treatment of malignant hemopathies or other immunodeficiency conditions. We report a case of a 27-year-old patient with severe aplastic anemia who developed Trichosporon inkin sepsis with skin lesions during aplasia after myeloablative allogeneic stem cell transplant. He was treated with liposomal amphotericin B but died from multiple organ failure. We then discuss the epidemiological, clinical and therapeutic features of these serious fungal infections compared to the published data.