インデックス付き
- Jゲートを開く
- Genamics JournalSeek
- サイテファクター
- コスモスIF
- シマゴ
- ウルリッヒの定期刊行物ディレクトリ
- 電子ジャーナルライブラリ
- レフシーク
- ハムダード大学
- エブスコ アリゾナ州
- 雑誌の抄録索引作成ディレクトリ
- OCLC-WorldCat
- プロクエスト召喚
- 学者の舵取り
- 道
- 仮想生物学図書館 (vifabio)
- パブロン
- ジュネーブ医学教育研究財団
- Google スカラー
このページをシェアする
ジャーナルチラシ
概要
Evaluation of the Protective Effect of Hibiscus sabdariffa L. Calyx (Malvaceae) Extract on Arsenic Induced Genotoxicity in Mice and Analysis of its Antioxidant Properties
Ilika Ghosh, Sonia Poddar and Anita Mukherjee
The present study envisages the antigenotoxic property of Hibiscus sabdariffa L. (Roselle) calyx extracts that is presumably attributed to its antioxidant properties. The dried calyx extracts of Roselle were administered to male albino mice at doses of 50, 100, and 150 mg/kg body weight for 7 days followed by a single dose of interperitoneal (i.p.) injection of sodium arsenite (2.5 mg/kg body weight) and the extent of DNA damage was analysed by widely used Comet assay. The results revealed that the calyx extract of Roselle inhibited the DNA damage induced by sodium arsenite in a dose dependent manner. The presence of phytochemical constituents such as polyphenols and flavonoids were ascribed to the observed changes. The antioxidant efficacy was substantiated by applying Ferric Reducing Antioxidant Power (FRAP) and 2, 2-di(4-tert-octylphenyl)-1-picrylhydrazyl (DPPH) assays.