細菌学および寄生虫学ジャーナル

概要

Evaluation of the Antibacterial Potential of the Phytochemicals in Leaf Extracts of Newboudia laevis on Uropathogens

Felix O Alao, Zacchaeus S Ololade*, Yusuf A. Fagge

This study was conducted to determine the secondary metabolites and antibacterial potential of the leaf extracts Newbouldia laevis on some uropathogen strains and also to carry out phytochemical screening of the sample. The antibacterial activity of N. laevis leaves extracted with methanol, hot and cold water were evaluated against medically important bacteria strains of Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Staphylococcus saprophyticus and Enterococcus faecalis. The results showed a remarkable inhibition of the bacteria growth against the tested organisms with Staphylococcus saprophyticus had highest activity (20 mm). In general, all the tested organisms showed a significant activity with the extracts. The conventional antibiotics used against these organisms showed that all the isolates were resistant to augmentin, ceftazidime, cefuroxime, and cloxacillin. The phytochemical analysis of the plants was carried out. The microbial activity of the Newbouldia laevis was due to the presence of various secondary metabolites. The GC-MS analysis showed that the most abundant phytochemical in the extract is linoleoyl chloride (76.3%). Hence, these plants can be used to discover bioactive natural products that may serve as leads in the development of new pharmaceuticals research activities.