幹細胞研究と治療のジャーナル

概要

Evaluation of Bone Marrow Derived Mesenchymal Stem Cell Potency on Wound Healing

Somia HA, Faten ZM and Shimaa HA

Background: Wound healing is a complicated process of skin repair after injury. This process requires a coordinated interplay among cells, growth factors, and extracellular matrix proteins. Mesenchymal stem cell coordinates the repair response by recruiting other host cells and secreting growth factors and matrix proteins also they are self-renewing multipotent stem cells that can differentiate into various lineages of mesenchymal origin such as bone, cartilage, tendon, and fat. In addition to multilineage differentiation capacity, MSCs regulate immune response and inflammation and possess powerful tissue protective and reparative mechanisms, making these cells attractive for treatment of different diseases.
Aim: The beneficial effect of exogenous bone marrow-derived mesenchymal stem cell on wound healing was observed but the mechanisms involved are barely understood. In this study, we examined signaling factors released by stem cells and their effects on the cells participating in wound healing .
Materials and Methods: Thirty female mice were randomly divided into three groups and were anesthetized and full thickness, wide deep wounds were made , then the 2nd generation of stem cells were injected intraperitoneally and intraregionally. These mice observed till complete healing then reverse transcription polymerase chain reaction was done for genes.
Results: This study found that bone marrow-derived mesenchymal stem cell promote the wound healing process.